PW01-010 – The effect of pregnancy on disease course in FMF
نویسندگان
چکیده
Methods All pregnant FMF patients treated at the FMF clinic of the Sheba Medical Center from May 2010 onwards, consenting to participate in this observational study, were studied prospectively for the occurrence of attacks. Attacks were recorded by patients in diaries provided on enrollment and relied by phone to a study coordinator on a monthly telephone call or on a pre-specified physician visit, whichever occurred first. In addition to noting attack occurrence, patients were instructed to record attack severity (on a 1-10 scale), attack location, duration, medications taken during the attack, colchicine dose prior to and during the attack, as well as ancillary signs and symptoms related to their FMF such as the occurrence of exertional leg pain.
منابع مشابه
PW01-033 – Phenotype – genotype in Armenian children with FMF
Introduction Familial Mediterranean Fever (FMF) is an ethnic disease for Armenian population and represents a significant health care problem. Frequency of carriers of MEFV mutations is 1:3, and the prevalence of FMF is rather high (14-100:10000). During the period between 2003 and 2012 there was a 4.5-fold increase of the total number of children with FMF. Many of these cases have severe clini...
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Introduction MEFV is the first identified autoinflammatory gene related to Familial Mediterranean Fever (FMF) disease. We previously the tested the hypothesize of epigenetic involvement in FMF, mainly based on the occurrence of FMF in patients without mutations and decreased MEFV transcripts in leukocyte samples independent from mutations. Our study showed that higher methylation level of MEFV ...
متن کاملPW01-032 – FMF-like state: genetic factors unrelated to MEFV
Introduction FMF is considered an autosomal recessive autoinflammatory syndrome caused by single gene (MEFV) mutations. Recently, it has been known that also heterozygous mutation carriers can suffer from a mild or incomplete form of FMF, named FMF-like disease. Among Armenians, who have relatively high carrier rate of MEFV mutations, single mutation has been detected in about 1/5 of symptomati...
متن کاملPW01-028 – Developing a new severity score for FMF
Introduction Severity is a basic feature that defines the prognosis of a disease. FMF presents with a variety of clinic and laboratory manifestations affecting severity, and evaluation of prognosis is an elusive task. Different severity scores have been previously proposed for FMF, and commonly used ones include Mor, Pras and Tel Hashomer severity scores however recent studies showed that there...
متن کاملPW01-031 – Treatment of FMF in middle and old age
Introduction Current recommendations for the treatment of familial Mediterranean fever (FMF) are based largely on the observation of FMF patients receiving colchicine therapy in childhood and young age. The adequate colchicine therapy led to more and more patients survive to that age. In addition, there are national peculiarities of FMF. For example, in Armenia, even before the massive use of c...
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